Primary Antibody Matched Pairs
ABclonal Technology VDR Rabbit mAb
This gene encodes vitamin D3 receptor which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors This receptor also functions as a receptor for the secondary bile acid lithocholic acid Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism though this receptor regulates a variety of other metabolic pathways such as those involved in immune response and cancer Mutations in this gene are associated with type II vitamin D-resistant rickets A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream Alternatively spliced transcript variants encoding different isoforms have been described for this gene A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon
Biotium GAD2 / GAD65 (GABAergic Neuronal Marker)(GAD2/2362), Biotin conjugate, 0.1mg/mL
This MAb recognizes a protein of 65 kDa, which is identified as glutamic acid decarboxylase 2 (GDA2). It is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. There are two forms of glutamic acid decarboxylases (GAD's) that are found in the brain: GAD2 (also known as GAD65) and GAD1 (also known as GAD67). GAD1 and GAD2 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GAD's are found in the brain, GAD2 localizes to synaptic vesicle membranes in nerve terminals, while GAD1 is distributed throughout the cell. A pathogenic role for GAD2 is identified in the human pancreas since it has been identified as an autoantibody and an auto-reactive T cell target in insulin-dependent diabetes. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes
Sino Biological Human Immunodeficiency Virus type 1 (HIV-1) p24 / Capsid Protein p24 ELISA Pair Set 5 Plates
The Human Immunodeficiency Virus type 1 (HIV-1) p24 / Capsid Protein p24 ELISA Pair Set is for the quantitative determination of Human Immunodeficiency Virus type 1 (HIV-1) p24 / Capsid Protein p24.The Sino Biological ELISA Pair Set is a solid phase sandwich ELISA (Enzyme-Linked Immunosorbent Assay). It utilizes a monoclonal antibody specific for Human Immunodeficiency Virus type 1 (HIV-1) p24 / Capsid Protein p24 coated on a 96-well plate. Standards and samples are added to the wells, and any Human Immunodeficiency Virus type 1 (HIV-1) p24 / Capsid Protein p24 present binds to the immobilized antibody. The wells are washed and a horseradish peroxidase conjugated mouse anti-Human Immunodeficiency Virus type 1 (HIV-1) p24 / Capsid Protein p24 monoclonal antibody is then added, producing an antibody-antigen-antibody "sandwich". The wells are again washed and TMB substrate solution is loaded, which produces color in proportion to the amount of Human Immunodeficiency Virus type 1 (HIV-1)
ABclonal Technology RBP4 Rabbit pAb
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
Biotium Granzyme B (NK/T-Cell Lymphoma Marker)(GZMB/3056), CF488A conjugate, 0.1mg/mL
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommende
Sino Biological Influenza A H7N9 (A/Anhui/1/2013) Hemagglutinin / HA ELISA Pair Set 5 Plates
The Influenza A H7N9 (A/Anhui/1/2013) Hemagglutinin / HA ELISA Pair Set is for the quantitative determination of Influenza A H7N9 (A/Anhui/1/2013) Hemagglutinin / HA.The Sino Biological ELISA Pair Set is a solid phase sandwich ELISA (Enzyme-Linked Immunosorbent Assay). It utilizes a monoclonal antibody specific for Influenza A H7N9 (A/Anhui/1/2013) Hemagglutinin / HA coated on a 96-well plate. Standards and samples are added to the wells, and any Influenza A H7N9 (A/Anhui/1/2013) Hemagglutinin / HA present binds to the immobilized antibody. The wells are washed and a horseradish peroxidase conjugated rabbit anti-Influenza A H7N9 (A/Anhui/1/2013) Hemagglutinin / HA polyclonal antibody is then added, producing an antibody-antigen-antibody "sandwich". The wells are again washed and TMB substrate solution is loaded, which produces color in proportion to the amount of Influenza A H7N9 (A/Anhui/1/2013) Hemagglutinin / HA present in the sample. To end the enzyme reaction, the stop solution
ABclonal Technology PICK1 Rabbit pAb
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
Sino Biological Anti-VSTM2L Antibody, Rabbit Polyclonal 100 µL
Produced in rabbits immunized with E. coli-derived Human VSTM2L fragment, and purified by antigen affinity chromatography.
Sino Biological Recombinant Human NCAM-1/CD56 Protein (Site-Specific APC Conjugation, His Tag) 25 Tests
A DNA sequence encoding the human NCAM1 (NP_001070150.1) (Met 1-Pro 603) was expressed with a C-terminal polyhistidine tag. The protein is site-specifically conjugated with APC (Excitation Max.= 651 nm, Emission Max.= 662 nm).
Biotium NME2 / nm23-H2 / NDPK-B (Suppressor of Metastasis)(CPTC-NME2-2), CF594 conjugate, 0.1mg/mL
The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human c-Myc promotor. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have
Medchemexpress LLC HLA-DPB1 Human His 50ug
Recombinant fragment of the human HLA-DPB1 (class II DP beta 1 chain) supplied as an N-terminal His-tagged, lyophilized protein for research use. The product corresponds to UniProt accession P04440 (residues R30-R223), has an approximate molecular weight of 26.8 kDa, and is >90% pure by reducing SDS-PAGE. Formulated in 10 mM Tris-HCl, 1 mM EDTA, 6% trehalose, pH 8.0, it is intended for biochemical and immunological applications and should be stored and handled according to the datasheet.
Sino Biological Human METTL1 Matched ELISA Antibody Pair Set 15 Plates
The Human METTL1 ELISA Pair Set is for the quantitative determination of Human METTL1.The Sino Biological ELISA Pair Set is a solid phase sandwich ELISA (Enzyme-Linked Immunosorbent Assay). It utilizes a monoclonal antibody specific for Human METTL1 coated on a 96-well plate. Standards and samples are added to the wells, and any Human METTL1 present binds to the immobilized antibody. The wells are washed and a horseradish peroxidase conjugated mouse anti-Human METTL1 monoclonal antibody is then added, producing an antibody-antigen-antibody "sandwich". The wells are again washed and TMB substrate solution is loaded, which produces color in proportion to the amount of Human METTL1 present in the sample. To end the enzyme reaction, the stop solution is added and absorbances of the microwell are read at 450 nm.
Biotium Annexin A1 / (Hairy Cell Leukemia Marker)(ANXA1/3566), 1mg/mL
Annexin A1 belongs to the annexin family. It plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. In resting conditions Annexin A1 is localized to the cytoplasm. Upon activation it is mobilized to the membrane and secreted. Annexin A1 and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. Expression of the ANXA1 gene is upregulated in hairy cell leukemia (HCL). Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue
